The protein FUS (fused in sarcoma)/TLS (translocated in liposarcoma), along with the gene products encoded by the Ewing’s sarcoma breakpoint region 1 (Ewsr1) and the TATA-box binding associated factor 15 (Taf15), are RNA and DNA-binding proteins which belong to the FET (FUS, EWS, TAF15) family of proteins [1]. The gene discussed is EWSR1; the disease is liposarcoma.