For example, gene NFATC1 has been associated with LN [48], gene PRKCB1 has been linked to the progression from DN to ESRD [49], transcription factor LEF1 encoded by gene LEF1 engaged in the Wnt signaling pathway is linked to CKD [50], and gene PRKAG2 is a fresh locus for CKD [51]. Here, PRKAG2 is linked to chronic kidney disease.