Stress-activated hypothalamic KORs were shown to increase PRL levels resulting in trigeminal sensitization, with effects in both male and female mice, suggesting that these KOR antagonists could potentially be used for migraine prophylaxis in both sexes, while decreasing PRL levels using the dopamine receptor agonist, cabergoline, seemed to be effective for reducing allodynia in only females, without any effect on males [125]. The gene discussed is PRL; the disease is migraine disorder.