Besides the role of inflammatory mediators such as calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide-38 (PACAP-38), which interact with the trigeminovascular system [8, 9] cyclic fluctuations in sex steroid hormones, including estrogen, progesterone and testosterone, are involved in the sex dimorphism in migraine and the genesis of migraine attacks [10, 11]. Here, ADCYAP1 is linked to migraine disorder.