Nevertheless, they could be explained also by an (in)direct dysregulation in PRL signalling (i.e. central and peripheral mechanisms) involving a higher expression of PRLR in sensory nerves and nociceptor sensitization in females [14–17, 78, 81], which may be related to the higher risk and the increase in the prevalence, recurrence, and severity or chronification of pain and migraine in females. The gene discussed is PRLR; the disease is migraine disorder.