Ferroptosis can occur through the transporter-dependent (extrinsic) pathway and the enzyme-regulated (intrinsic) pathway.36 We observed that GPX4 protein expression was markedly elevated and Fe2+ and MDA contents were significantly reduced in tumor cells treated with erastin and post-MI plasma exosomes, indicating that ischemic heart-derived exosomes regulate the intrinsic enzyme-regulated ferroptosis pathway. This evidence concerns the gene GPX4 and neoplasm.