For instance, the polyunsaturated fatty acid biosynthesis pathway may be a marker for predicting the efficacy of ferroptosis-mediated cancer therapy.12 Endogenous glutamate is critical for the sensitivity of ferroptotic induction following the inhibition of system XC− in lung adenocarcinoma LUAD cells.13 Suppression of iron-sulfur cluster biosynthetic enzyme NFS1 cooperates with inhibition of cysteine transport to trigger ferroptosis and slow lung tumor growth.14 However, the association between HF and ferroptosis sensitivity in cancer is not completely understood. This evidence concerns the gene NFS1 and cancer.