Specifically, the present study uncovered for the first time a new signaling pathway linking heart to tumor in the setting of MI: MI → Heart-derived Exosomes → Tumor Cells → Release of miR-22-3p from Exosomes → Repression of ACSL4 → Inhibition of lipid Peroxidation → Suppression of Susceptibility to Ferroptosis Activation → Aggravation of Tumor Growth (Fig. 8). Here, ACSL4 is linked to neoplasm.