Western blotting showed increased LAMP-2 levels in frontal grey (F = 12.2, p = 0.0003) (Fig. 6A-B) and white matter (F = 9.7, p = 0.0009) (Fig. 6C-D) of both FTD-GRN and FTD-C9orf72 cases, whereas levels were unchanged in parietal white matter (Fig. 6E-F). This evidence concerns the gene LAMP2 and frontotemporal dementia.