CNP and frontotemporal dementia: In agreement with our lipidomic data, western blotting showed significant loss of the myelin markers proteolipid protein (PLP) (ANOVA, F = 12.03, p = 0.0003), 2’,3’-Cyclic nucleotide 3’-phosphodiesterase (CNP) (F = 11.64, p = 0.0003) and myelin basic protein (MBP) (F = 4.84, p = 0.018), in frontal white matter of FTD-GRN cases (Fig. 4A-B).