As reported in Fig. 5, hit 17 treatments induced a dose-dependent increase of phosphorylated ATM (p-ATM), CHEK1 (p-Chk1), CHEK2 (p-Chk2) and H2AX (γH2AX) suggesting the activation of DNA damage response pathway in MM cell lines. The gene discussed is H2AX; the disease is Miyoshi myopathy.