NR1I2 and obesity due to melanocortin 4 receptor deficiency: Ppp1r3c is enriched in adipocytes and is noteworthy that it increases during the browning process (Keinan et al., 2021) and Cyp2b10 is known to be regulated by nuclear receptors like PXR, repression of which leads to obesity and exacerbation of metabolic disease by disrupting metabolism of fatty acids (Chen et al., 2021).