GFER and epilepsy: The HPO IC3 panel had an average rank of the causative variant of 1.60 (median: 1, range: 1–7) and median rank ratio of 0.011 (range: 0.003–0.063), while the clinical epilepsy panel had an average rank of 2.05 (median: 1, range: 1–7) and median rank ratio of 0.014 (range: 0.005–0.212) (Figure 3).