The results showed that the levels of serum NSE and SCC in the study group were significantly higher than those in the control group, suggesting that NSE and SCC were related to the occurrence of lung cancer, which was consistent with the results of previous studies.18, 19 The results showed that the levels of NSE and SCC decreased significantly after radiotherapy, suggesting that radiotherapy can improve the levels of NSE and SCC, which may be attributed to the killing and inhibitory effects of radiotherapy on tumors, further reducing the malignancy of tumors. Here, ENO2 is linked to lung cancer.