The ROC curve analysis showed that the AUC of NSE and SCC levels in serum for predicting tumor recurrence and metastasis in patients with lung cancer radiotherapy was 0.848 and 0.755, respectively, the critical values were 21.98 ng/mL and 1.59 ng/mL, and the sensitivity was 92.86% and 82.14%, and the specificity was 82.14%, 71.87%, 62.96%, as exhibited in Fig. 1. This evidence concerns the gene ENO2 and lung cancer.