STAT3 and familial pancreatic carcinoma: In pancreatic cancer, IGF-IR, STAT3, HIF-1α, IL-6, IGF-1, amongst others, have been described to be active and linked to the HSP90 pathways (Bruns et al. 2000; Wei et al. 2003; Xu et al. 2005; Lang et al. 2007).