Moreover, when looking at the broader cellular context, lymphocytes from clusters 7 and 28 expressed significant TGFB1 and tumor clusters 3, 8, and 14 expressed substantial CSF1, which promote immunosuppressive and pro-inflammatory properties in macrophages, respectively (Additional file 13 and Additional file 3: Table S2) [4]. Here, TGFB1 is linked to neoplasm.