For each of tumor 1 and tumor 4, there were dispersed spots that co-clustered (into tumor 1 hypercellular 3 and tumor 4 dispersed) wherein there was significant enrichment in vascular genesis-related pathways and Wikipathways VEGFA-VEGFR2 pathway with associated enrichment of inflammatory pathways, PI3K-AKT(-mTOR) pathways, and depletion of neuron-related pathways (Fig. 8C and not shown). Here, MTOR is linked to neoplasm.