Interestingly, activation of NF-E2-related factor 2 (NRF2), key regulator of antioxidant defense pathways, reduces Aβ secretion and modulates cytokine release and oxidative stress in PSEN1 mutant astrocytes [4], suggesting that targeting NRF2 in AD astrocytes could be a potential therapeutic strategy. This evidence concerns the gene NFE2L2 and Alzheimer disease.