Meanwhile, SPTLC2 plays a similar role as SPTLC1 in the SPT function.<h4>Methods</h4>To explore the genetic role of SPTLC1 and SPTLC2 in ALS, we analyzed the rare protein-coding variants in 2011 patients with ALS and 3298 controls from the Chinese population with whole exome sequencing. Here, AGXT is linked to amyotrophic lateral sclerosis.