These 5 above-mentioned pathophysiological conditions before the IS event have been described in literature and can be elaborated further:A rise in the erythrocyte indexes B.RDW.CV and B.RDW.SD and ferritin levels with lowering trends in B.Hb, B.Hct, and B.RBC values before IS diagnosis indicate early hidden anemia. The gene discussed is GSTM1; the disease is anemia (phenotype).