In fact, it was previously characterized that the plant defensin NAD1 can interact with PIP2, first as a dimer, then forming an oligomeric arrangement in the plasma membrane of fungi and tumor cells, in a process that culminate with membrane permeabilization, through blebs formation followed by membrane rupture, possibly involving the disruption of cytoskeleton-membrane interactions [50]. This evidence concerns the gene MT-ND1 and neoplasm.