We performed the LASSO regression analysis to screen the coefficients related to the OS of patients with BC (Fig. 8N), and the trajectories of variables were plotted in Fig. 8O. Finally, the significant variables, including IGF2BP1 level, T stage, PR status, ER status, HER2 status, and PAM50 subtype, were entered as candidates in the nomogram. The gene discussed is IGF2BP1; the disease is breast cancer.