In addition, GATA-binding protein 3 (GATA3) and vesicular disease fluid protein-15 (GCDFP-15) are useful in the diagnosis of breast cancer metastases and can also play an important role in the differential diagnosis, and positive expression of GCDFP-15 is a highly sensitive (55–76%) and specific (95–100%) marker that can correctly identify malignant lesions identified as metastatic breast cancer [14–16]. This evidence concerns the gene PIP and breast cancer.