LZTFL1 and neoplasm: Since AKT is known to promoter tumor cell proliferation/tumor growth via inhibition of P21/P27 and upregulation of CDKs/cyclin D1, destabilization of AKT by LZTFL1 could downregulate the signaling in the AKT-P21/P27-CDK4/cyclin D1 axis, leading to reduced cell cycle progression and tumor cell growth (Fig. 7d).