To further understand the molecular mechanism by which LZTFL1 regulates the cell cycle progression in ccRCC cells, Gene set enrichment analysis (GSEA) [24] was performed to identify gene sets that correlate with LZTFL1 expression in TGCA cohorts that express high and low LZTFL1 (Supplementary Fig. 3), respectively. Here, LZTFL1 is linked to nonpapillary renal cell carcinoma.