As LZTFL1 did not impact the transcription of AKT in kidney tumor cells (Supplementary Fig. 4) and the GO suggested that LZTFL1 may be involved in proteasomal protein catabolic process and ubiquitination (Fig. 4a), we tested whether LZTFL1 regulates the stability of AKT. Here, LZTFL1 is linked to kidney neoplasm.