A previous study by our group has shown that NSCLC patients with elevated IKKα expression have significantly reduced overall survival than those with low IKKα expression and that IKKα regulates NSCLC cell migration by forming a complex with DARPP-32 to influence the noncanonical NF-κB cell signaling pathway25. The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.