Specifically, we observed greater inactivation (i.e., phosphorylation) of PP1α proteins in NSCLC cells stably overexpressing exogenous DARPP-32 upon transient expression of constitutively active IKKα cDNA plasmids relative to wild-type or kinase-dead IKKα control expression vectors. This evidence concerns the gene CHUK and non-small cell lung carcinoma.