DARPP-32 and t-DARPP promote non-small cell lung cancer growth through IKKα-dependent activation of noncanonical NF-κB2 signaling based on our previous findings showing DARPP-32 and t-DARPP each have oncogenic properties in lung cancer cells, including regulation of cell survival and migration25. The gene discussed is CHUK; the disease is non-small cell lung carcinoma.