CHUK and lung cancer: Immunoblotting experiments demonstrated a reduction in the expression of phosphorylated PP1α (i.e., inactive) and phosphorylated ERK (i.e., activated) in lung tumor tissue lysates harvested from mice challenged with IKKα-ablated HCC827 lung cancer cells relative to lysates harvested from mice that were administered control LacZ shRNA-transduced HCC827 cells (Fig. 7c).