We stained mouse lung tumor tissues with hematoxylin and eosin (H&E), and we observed a necrotic core within tumors derived from the mice challenged with stable IKKα-depleted HCC827 cells, whereas lung cancer tissues harvested from mice that received LacZ shRNA-transduced HCC827 cells had little to no necrosis (Fig. 7d). This evidence concerns the gene CHUK and lung cancer.