ADAMTS17 and Weill-Marchesani syndrome: ADAMTS17 is involved in the function of FBN1 in human tissues, and both heterozygous mutations of FBN1 and homozygous mutations of ADAMTS17 can cause WMS; these points strongly suggest the interaction between ADAMTS17 and FBN1, and we demonstrated that ADAMTS17 promotes extracellular microfibril biogenesis in vitro22–25,27.