The present study aims to detect the prognostic significance of serum miR-222-3p, miR-26b-5p, EBV-miR-BHRF1-2-5p, and EBV-miR-BHRF1-2-3p and the significance of BMI1 and PIM2 proteins to differentiate between infiltrative and non-infiltrative BM in DLBCL. Here, BMI1 is linked to diffuse large B-cell lymphoma.