Furthermore, TAMs promote tumor progression and invasion by secreting matrix metalloproteinases (MMPs) [54], and of these, MMP1 can activate cdc25a/CDK4-cyclin D1 and p21/cdc2-cyclin B1 complexes to accelerate the growth of colon cancer cells via the regulation of MYC expression [55]. The gene discussed is CCND1; the disease is neoplasm.