Numerous studies have shown that the MYC-dependent pathway in tumor cells can indirectly affect the expression of cytokines in the TIME, such as the reduction in the expression of interleukin-2 (IL-2), interferon-γ (IFN-γ), and perforin [16] and the increase in the expression of interleukin-6 (IL-6) [17]. This evidence concerns the gene MYC and neoplasm.