MAPK1 and nonpapillary renal cell carcinoma: Moreover, we elucidated a new mechanism by which ZNF582 overexpression up-regulates TJP2 protein expression, which leads to the enhancement of combination of TJP2 and ERK2 protein, up-regulation of ERK2 expression level and down-regulation of ERK2 phosphorylation level, therefore suppressing the growth and metastasis of ccRCC.