Finally, we detected the expression of apoptosis and invasion related proteins in ZNF582 overexpression and knockdown ccRCC cells and mouse kidney tumors, our results determined that, after ZNF582 overexpression, the protein expression of Cleaved Caspase-3 and E-cadherin is significantly increased and the protein expression of BCL-2 and N-cadherin is significant decreased. This evidence concerns the gene CASP3 and nonpapillary renal cell carcinoma.