Finally, we detected the expression of apoptosis and invasion related proteins in ZNF582 overexpression and knockdown ccRCC cells and mouse kidney tumors, our results determined that, after ZNF582 overexpression, the protein expression of Cleaved Caspase-3 and E-cadherin is significantly increased and the protein expression of BCL-2 and N-cadherin is significant decreased. Here, CASP3 is linked to kidney neoplasm.