For instance, hypermethylated ZNF582 is associated with aggressive progression and poor prognosis of oral cancer [10]; ZNF582 hypermethylation promotes metastasis of nasopharyngeal carcinoma by regulating the transcription of adhesion molecules Nectin-3 and NRXN3 [9]; ZNF582 promoter methylation can predict cervical cancer radiosensitivity and ZNF582 protein overexpression reduces tumor radiosensitivity [11]. Here, ZNF582 is linked to lip and oral cavity carcinoma.