For instance, methylated ZNF582 gene is used as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions [20]; hypermethylated ZNF582 is an effective biomarker for detection of oral cancer [8, 21]; abnormal DNA methylation of ZNF582 gene is a potential biomarker of esophageal squamous cell carcinoma [22]; hypermethylated ZNF582 gene is associated with invasive progression and poor prognosis of oral cancer [10]; ZNF582 methylation level also can predict the radiosensitivity of cervical cancer [23]. This evidence concerns the gene ZNF582 and esophageal squamous cell carcinoma.