EWSR1 and melanoma: In control cell lines, CREM loss reduced proliferation, but to a lesser extent as compared to the consequences of CREM and EWSR1::CREM protein loss in the fusion bearing cell line, As an example of the scale difference, CREM siRNA treatment in the melanoma cell line WM164 reduced proliferation from 69% to 58%, while the CREM siRNA in the fusion bearing CHL-1 cell line resulted in a 84% to 4% reduction.