ALDH1A1 and Parkinson disease: Accordingly, transcriptomic and proteomic studies in post-mortem PD patients brains, both familial and idiopathic, identified the selective reduced expression of ALDH1A1 among the molecular determinants involved in the preferential susceptibility of SNpc dopaminergic neurons1,21–23, thus sustaining that the resulting DOPAL accumulation might be among the driving forces for dopaminergic neuron degeneration.