The presence of an overtly sarcomatous differentiation (LGMT DICER1 vs. SARC DICER1), anatomical location (SARC DICER1 vs. PIS DICER1) and the identification of a DICER1 hotspot PV, will usually be sufficient to classify DICER1-associated mesenchymal neoplasms. This evidence concerns the gene DICER1 and mesenchymal cell neoplasm.