While disruption of DICER1 has been shown to lead to downregulation of miRNAs and enhance stemness and epithelial-to-mesenchymal transition in colorectal cancer cells29, as stated above, additional PVs in oncogenes and tumor suppressors other than DICER1 PVs, may contribute to this transition from a cystic to a mesenchymal phenotype. The gene discussed is DICER1; the disease is colorectal cancer.