At the phosphoprotein level, the overrepresented phosphorylation of CTNNB1 (T551, S191) and CTNND1 (S346, Y865), were observed in the A-ESCC phase (Kruskal–Wallis test, FDR < 0.05, A-ESCC vs. NT ratio ≥ 2) (Supplementary Fig. 4q). This evidence concerns the gene CTNND1 and esophageal squamous cell carcinoma.