MACF1 and esophageal squamous cell carcinoma: In addition, the validations of the impacts of other genes (e.g., AKAP9, MACF1, etc.)in ESCC progression are lacking, even though we believe the comprehensive proteogenomic landscape of early-stage ESCC at the multi-omics level will provide a valuable resource for ESCC and considerable insights into understanding ESCC molecular mechanisms.