As well as in the TCGA cohort15, the GO enrichment disclosed that those overlapped SUPs were related to DNA replication and cell cycle (e.g., MCM3/4/5/6, CCNK, PPP1R8, etc.), and ECM signaling (e.g., ITGA2/3/5, LAMA3/5, etc.), which was also overrepresented in the tumor tissues compared to the paired non-cancerous adjacent tissues (NATs) in the Liu’s cohort26 (Supplementary Fig. 4j, k). Here, MCM3 is linked to neoplasm.