DCTN2 and esophageal squamous cell carcinoma: In addition, the APOBEC signature was the dominant signature in the non-drinking/smoking ESCC patients, and the significant mutation of DCTN2 upregulated the protein level of DCTN2, and displayed positive impacts on RUVBL1 and thus activated DNA replication, implying the potential effects of CB-6644 in the non-drinking/smoking ESCC patients.