MAPK1 and esophageal squamous cell carcinoma: Accordingly, we confirmed that co-overexpression of PGK1 and ERK2 in the above four kinds of ESCC cell lines (KYSE150, KYSE70, ECA109, and TE-8) promoted their proliferation most profoundly, compared to cells overexpressing either PGK1 or ERK2 (t-test, p < 1.0E–4) (Fig. 8g and Supplementary Fig. 8e, and Supplementary Data 7g).