CD8A and neoplasm: Consequently, the efferocytosis-related signaling pathways are triggered, resulting in the reduction of proinflammatory cytokines, inhibition of M1-macrophages polarization, restriction of antigen presentation of macrophages, increase of Treg cells while decrease of CD8+ T cells in tumor microenvironment (TME), further promoting tumor proliferation, invasion, and metastasis6,7.