Dupilumab is a fully human monoclonal antibody that acts as IL-4Rα antagonist to block the active biological effects of IL-4 and IL-13 in carrying out type 2 immune responses including some symptoms of PN.4, 14, 15, 17 Meanwhile, the exact pathogenesis of PN remains ambiguous. The gene discussed is IL4; the disease is poikiloderma with neutropenia.