It is also possible that PN is clinically correlated to atopic dermatitis (AD) as Th17 related cytokines are found to be potential contributors in the pathogenesis of AD in recent years while dupilumab has a fair number of reported cases of being successful in treating patients with severe, intractable AD.24, 25, 26, 27, 28, 29, 30 These discoveries put forward the possibility of Th17/IL-17 inflammation-modulating therapies in becoming a beneficial treatment target for PN patients in the future. The gene discussed is IL17A; the disease is Alzheimer disease.