In the research cohort, the total positive rate of NRP‐1/CD304 was 14.81% (44/297), mainly distributed in BPDCN (100%, 6/6), B‐ALL (48.61%, 35/72), and AML (4.48%, 3/67), with statistically significant differences (p < 0.01). The gene discussed is NRP1; the disease is acute lymphoblastic leukemia.