The indirect effect of psychological distress via IL‐1β, TNF‐α, and IL‐4 on the MMSE was significant and negative (=−0.34, =−0.32, =−0.32, respectively; 95% CI [−0.59 to −0.17], [−0.52 to −0.16], [−0.54 to −0.13]). Here, IL1B is linked to Abnormal emotional state.