KEAP1 and cancer: For example, PAQR4 physically interacts with NRF2 and blocks the interaction between NRF2 and KEAP1, enhancing the sensitivity of cancer cells to chemotherapy.[46] Overexpression of NRF2 renders NH3 cells resistant to GPX4 inhibitors by promoting ferroptosis.[47] In this study, we identified DDRGK1 as a novel regulator of NRF2.