In summary, we demonstrated that 6 lncRNAs (LINC01116, KDM4A‐AS1, KMT2E‐AS1, LINC00839, UBL7‐AS1, DLX6‐AS1) related to ESCC progression could encode short peptides in ESCC by the combined analysis of WGCNA, prior ribosome‐seq data, ORF prediction, MS identification, and western blotting assay. The gene discussed is UBL7; the disease is esophageal squamous cell carcinoma.