In this study, we simultaneously identified six lncRNA open reading frames (ORFs) with peptide‐coding abilities including lysine‐specific demethylase 4A antisense RNA 1 (KDM4A‐AS1) ORF by combining weighted gene co‐expression network analysis (WGCNA) for ESCC clinical samples, ribosome footprints, ORF prediction, mass spectrometry (MS) identification, and western blotting. Here, KDM4A is linked to esophageal squamous cell carcinoma.