SOX10 and spina bifida: The notochordal signaling is responsible for neural tube closure, while its defects result in spina bifida and exencephaly.[32] Gene Ontology (GO) term enrichment analysis revealed the capacity of SOX10+ and Sox10+ subpopulations in regulating epithelial tube morphogenesis, mesenchyme development, tube formation, and cartilage development (Figure 2H).