PIEZO1 could also be gated by osmotic pressure,[97] and conditional knockout of Piezo1 leads to overhydrated red blood cells with increased osmotic fragility.[98] However, gain‐of‐function mutations in PIEZO1 are associated with dehydrating red blood cell disease xerocytosis.[99] We previously reported that ECM stiffness accelerated the degeneration of adult NP cells by activating PIEZO1,[89] but understanding the role of PIEZO1, which regulates osmotic pressure in embryonic NC/NP cells, necessitates further experimental evidence. Here, PIEZO1 is linked to erythrocyte disorder.