Due to its broad expression, being downstream of different signalling events and driving expression of a myriad of critical neuronal genes, alterations of CREB activity and/or CREB expression have been indeed reported in neurodegenerative conditions such as AD or PD in cultured neurons, in vivo transgenic animal models and humans (Pugazhenthi et al., 2011; Xu et al., 2022). This evidence concerns the gene CREB1 and Alzheimer disease.