ATP7B and Wilson disease: Wilson's disease, characterised by aberrant copper transport and progressive hepatic and neurological disease caused by Atp7b mutation, was successfully reversed in Atp7b−/− knockout murine fetuses with LV vector LSP.GFP.huATP7B delivered intracardiac at E10, resulting in increased ATP7B expression, decreased hepatic copper content, and restoration of normal liver morphology.125