Wilson's disease, characterised by aberrant copper transport and progressive hepatic and neurological disease caused by Atp7b mutation, was successfully reversed in Atp7b−/− knockout murine fetuses with LV vector LSP.GFP.huATP7B delivered intracardiac at E10, resulting in increased ATP7B expression, decreased hepatic copper content, and restoration of normal liver morphology.125. This evidence concerns the gene ATP7B and nervous system disorder.