Therefore, according to the mature experimental skills of our laboratory,34 we next use the Cre‐Loxp system to artificially knock down the expression of CDK5 by injecting AAV‐hSyn‐Cre virus into the different hippocampal regions of CDK5flox/flox mice by stereolocalization of brain regions to evaluate whether the pathological changes of BPD could be induced. This evidence concerns the gene RIC8B and bronchopulmonary dysplasia.