Furthermore, at hospital admission only ~ 3% of elderly patients with type 2 diabetes were treated with the new classes of anti-diabetes drugs, such as GLP-1 RA, DPP-4 inhibitors, and SGLT2 inhibitors, despite it has been shown to be effective, and safe drugs in elderly patients and we observed a trend towards an increase in their prescriptions in the years 2018–2019 compared to the years 2010–2011. This evidence concerns the gene DPP4 and type 2 diabetes mellitus.