Moreover, the methylation levels of the CCNE1 promoter were lower in BLCA, CESC, HNSC, ESCA, LUSC, LIHC and READ and higher in BRCA, KIRP, KIRC, PRAD, PCPG and THCA than in corresponding normal tissues, suggesting that CCNE1 promoter methylation may lead to its downregulation or upregulation in various tumor tissues and that low methylation levels of the CCNE1 promoter may be related to abnormally high CCNE1 expression in UCEC. Here, CCNE1 is linked to neoplasm.