The extra-ocular features seen in FOXC1-related ARS include many that are also present in 6p25 deletion syndrome, namely tooth abnormalities, sensorineural hearing loss, congenital heart defects, cerebellar abnormalities and craniofacial dysmorphisms such as maxillary hypoplasia and hypertelorism [2, 49]. This evidence concerns the gene FOXC1 and Down syndrome.