Herein, we uncovered FBXL19 and FOXM1 as regulators of lung injury in Spn-induced pneumonia immature mice and validated a mechanism wherein FBXL19 bound to FOXM1 and induced the ubiquitination and degradation of FOXM1, thus attenuating lung injury in Spn-induced pneumonia immature mice. Here, FBXL19 is linked to pneumonia.