A similar trend was observed for the biomarkers while comparing the clinical groups FTD vs SCD where the synaptic proteins had significant diagnostic values as follows: SNAP25 (AUC = 0.83), Ng (AUC = 0.79), VAMP2 (AUC = 0.77), NPTX2 (AUC = 0.70). The gene discussed is NRGN; the disease is Schnyder corneal dystrophy.