A synaptic protein progressively decreasing with the disease state in genetic FTD is neuronal pentraxin-2 (NPTX2), mainly present as an extracellular protein in the synaptic cleft [7] Neuronal pentraxins, including NPTX2, are involved in synaptic plasticity, and their lower levels have been reported in patients with DLB, FTD, and PD as well [16]. This evidence concerns the gene NPTX2 and Lewy body dementia.