Interestingly, when comparing chromatin accessibility changes in colorectal cancer organoids treated with oxaliplatin, fibroblast growth factor receptor 1 (FGFR1) and oxytocin receptor (OXTR) were identified among upregulated genes, however these results were observed only in a subset of patients, highlighting complex heterogeneity of epigenetic and transcriptional response to cancer treatment [180]. The gene discussed is OXTR; the disease is colorectal cancer.