Long non-coding RNA HMMR-AS1, a competing endogenous RNA (ceRNA) for miR-138, is highly expressed in lung adenocarcinoma tissues, promotes tumor proliferation and invasion, and is closely associated with tumor size, TNM stage, and prognosis, while HMMR-AS1-miR-138-sirt6 plays an important role in the origin of lung cancer [20]. Here, SIRT6 is linked to lung adenocarcinoma.