Liang-Yan Chen has reported that the circ-ERBIN-mediated miR-125a-5p-5p/miR-138-5p/4EBP-1 axis activated the key mechanism of HIF-1α, which increased the proliferation and migration ability of intestinal cancer cells, suggesting that circ-ERBIN could be a potential target for Colorectal Cancer CRC therapy [21]. This evidence concerns the gene HIF1A and colorectal carcinoma.