Similar to this finding, Liu et al. have demonstrated that the decreased HOTTIP could accelerate the apoptosis of colorectal cancer cells [42], and a recent article has unraveled that the restoration of miR-30b-3p could diminish the apoptosis of lipopolysaccharide-treated alveolar epithelial cells in acute lung injury (ALI) [43]. Here, HOTTIP is linked to acute respiratory distress syndrome.