Consistent with this outcome, Mao et al. have unearthed that the knockdown of HOYYIP is able to restrict the development of osteoarthritis [45], and it has been discussed that the down-regulation of miR-30b-5p is accompanied with increase of TNF-α, IL-6 and IL-8 in ALI patients [46]. The gene discussed is CXCL8; the disease is osteoarthritis.