Phosphoglycerate kinase 1 (PGK1) is a vital glycolytic enzyme that produces adenosine triphosphate through catalyzing the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate [25], which has been implicated in spinal muscular atrophy [26] and collagen-induced arthritis (CIA) [27]. The gene discussed is PGK1; the disease is proximal spinal muscular atrophy.