In accordance with the finding, Zheng et al. have observed that the suppression of HOTTIP restrained the activation and proliferation of hepatic stellate cells (HSCs) in liver fibrosis [37], Li et al. have elucidated that the down-regulation of HOTTIP has the capacity to reduce the proliferation of trophoblast cells in preeclampsia [38], and it has also been clarified that the overexpressed miR-30 could suppress the proliferation of HSCs in liver fibrosis [39]. The gene discussed is HOTTIP; the disease is Hepatic fibrosis.