ABCB1 and neoplasm: However, majority of the Cur-nanomedicines are still facing grander challenges due to recognition by the reticuloendothelial system, non-specific accumulation into various body tissues, poor penetration and accumulation in the TME, and multidrug resistance due to overexpressed P-glycoproteins in the tumor cells which ultimately hampers the clinical significance of Cur-nanomedicines.