DICER1 and colorectal carcinoma: Huang et al. found that tRF/miR-1280 reduced CRC growth and metastasis by inhibiting Notch signaling [48], while Luan et al. found that the expression of tRF-20-MEJB5Y13 was increased under hypoxic conditions, and that tRF-20-MEJB5Y13 upregulation by Dicer1 led to hypoxia-induced invasion and migration of CRC cells [49].