CLDN1 and colorectal carcinoma: Moreover, Chen et al. demonstrated that tRF-phe-GAA-031 and tRF-VAL-TCA-002 were significantly associated with distant metastasis of CRC tumor cells [70], while Luan et al. found that tRF-20-M0NK5Y93 promotes CRC cell migration and invasion, partly by regulating Claudin-1 during endothelial cell transformation [71].