Among the 20 patients who developed subsequent LN, 23.5% of them had heavy proteinuria (urine protein > 3.5 g/day), 9/14 (64.3%) of them had documented hypoalbuminemia (serum albumin < 3.5 mg/dL), and 10% of them had an eGFR < 60 mL/min/1.73m2 at their LN diagnosis. The gene discussed is ALB; the disease is Hypoalbuminemia.