A recent study on the prognosis of lung cancer has shown that female LUADs characterized by wild-type TP53, high levels of immune infiltration, and enrichment of immune-related pathways or compartments such as INF-γ and TNF signaling and macrophages-monocytes obtained longer survival, whereas male with lung squamous cell carcinoma, wild-type TP53 tumor cells, and enriched TGF-β signaling pathway showed poor prognosis [50]. This evidence concerns the gene TGFB1 and squamous cell lung carcinoma.