Especially, the NSCLC-derived exosomes from tumor cells (e.g., A549, H460, and H1299) carry different expression levels of multitudinous proteins (e.g., epithelial cell adhesion molecule (EpCAM) and carcinoembryonic antigen (CEA)), resulting in distinct surface phenotypes correlated with cancer occurrence and progression [20–22]. The gene discussed is CEACAM5; the disease is cancer.